| Date | Day | Opponent | Time | Score | |
| Sat., Aug. 14 | Sat | HOUSTON TEXANS | 5:00 PM | 19-16 | W |
| MON., Aug. 23 | Mon | @TENNESSEE TITANS | 5:00 PM | 10-24 | L |
| Sat., Aug. 28 | Sat | @CHICAGO BEARS | 5:30 PM | 14-9 | W |
| THU. SEP. 2 | Thurs | WASHINGTON REDSKINS | 7:00 PM | 20-10 | W |
| September 12, 2010 | Sun | @ST. LOUIS Rams | 1:15 PM | 17 - 13 | W |
| September 19, 2010 | Sun | @ATLANTA FALCONS | 10:00 AM | 7 - 41 | L |
| September 26, 2010 | Sun | OAKLAND RAIDERS | 1:15 PM | 24 - 23 | W |
| October 3, 2010 | Sun | @SAN DIEGO CHAR5GERS | 1:15 PM | 10 - 41 | L |
| October 10, 2010 | Sun | NEW ORLEANS Saints | 1:05 PM | 30 - 20 | W |
| October 24, 2010 | Sun | @SEATTLE SEAHAWKS | 1:05 PM | 10 - 22 | L |
| October 31, 2010 | Sun | TAMPA BAY BUCCANEERS | 1:15 PM | 35 - 38 | L |
| November 7, 2010 | Sun | @MINNESOTA VIKINGS | 11:00 AM | 24 - 27 | L |
| November 14, 2010 | Sun | SEATTLE SEAHAWKS | 2:15 PM | 10 - 20 | L |
| November 21, 2010 | Sun | @KANSAS CITY CHIEFS | 11:00 AM | 13 -31 | L |
| November 29, 2010 | Mon | SAN FRANCISCO 49ERS | 6:30 PM | 6 - 27 | L |
| December 5, 2010 | Sun | ST. LOUIS RAMS | 2:15 PM | 6 - 19 | L |
| December 12, 2010 | Sun | DENVER BRONCOS | 2:15 PM | 43 - 13 | W |
| December 19, 2010 | Sun | @CAROLINA PANTHERS | 11:00 AM | 12 - 19 | L |
| December 25, 2010 | Sun | DALLAS COWBOYS | 5:30 PM | 27 - 26 | W |
| January 2, 2011 | Sun | @SAN FRANCISCO 49ERS | 2:15 PM | 7 - 38 | L |